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Availability: In Stock
Brand Name : Velpanat
International Trade Name : Epclusa
Composition : Velpatasvir and Sofosbuvir
Manufactured by : Natco Pharma Ltd.
Strength : Velpatasvir 100 mg and Sofosbuvir 400 mg
Form : Tablets
Packing : Pack of 28 Tablets
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Velpanat combines 2 drugs into a single tablet - Sofosbuvir (a nucleotide analog NS5B polymerase inhibitor) and Velpatasvir (an NS5A inhibitor). It is an FDA-approved generic version of Epclusa that is used for treating hepatitis C virus (HCV) infection. It’s approved to treat all 6 main genotypes of HCV. Hepatitis C genotypes are different strains, or types, of the virus.
This hepatitis medication is approved for use in people who have tried other HCV medications in the past and were unable to clear the virus. It’s also used for people who are new to HCV treatment. People with or without cirrhosis are able to use Velpanat tablets. Cirrhosis is serious scarring in the liver that prevents it from functioning properly. This medicine is approved for use in people with compensated cirrhosis (a liver disease that typically doesn’t cause symptoms) and decompensated cirrhosis.
Decompensated cirrhosis is when the liver is close to failure and causing serious health issues. People with decompensated cirrhosis will also need to take ribavirin (Rebetol) with Velpanat Velpatasvir Sofosbuvir.
The active ingredients in Velpanat tablets are Sofosbuvir 400 mg and Velpatasvir 100 mg, which act by weakening the activity of proteins needed by hepatitis C. Sofosbuvir blocks the action of an enzyme called ‘NS5B RNA-dependent RNA polymerase’, while Velpatasvir targets a protein called ‘NS5A’. By blocking these proteins, this fixed-dose combination (FDC) drug significantly reduces and stops the production of new copies of the hepatitis C virus. Viruses that can’t reproduce eventually die and are cleared from the body. The goal of treatment is to rid the body of the hepatitis C virus. Clearing the virus from the body will reduce liver inflammation and prevent additional scarring.
Take 1 tablet once a day. It can be taken with or without food. However, taking it with food might help decrease any nausea that could be caused by the medication. Be sure to follow your doctor’s instructions and take a tablet every day for 12 weeks. Using a reminder tool can be helpful in making sure you take your medicine each day.
You may start to feel better a few days or weeks after you start taking Velpatasvir/Sofosbuvir, but you still need to take the full 12 weeks of treatment. It’s important to both take the full treatment and avoid missing any doses. These steps help the medication succeed in clearing the HCV from your body. Your doctor will test you before and during treatment, and again 12 weeks after you finish taking this HCV drug. This last test will determine if you are “cured” of hepatitis C.
You’re considered cured of hepatitis C when you have achieved sustained virologic response (SVR), which means the virus is no longer detectable in your blood.
Dosage information for patients with decompensated liver cirrhosis - Like Velpanat, ribavirin comes as a pill, but it’s taken twice a day. Typically, your dose of ribavirin will be based on your weight. It may also be based on your hemoglobin levels and your kidney function.
If you have any questions or concerns about your treatment, talk with your doctor. They can help resolve any issues for you and help you get the most out of your treatment.
• Shortness of breath
• Chest pains
• Extreme tiredness
• Low blood iron (anemia)
• Muscle weakness
• Jaundice (yellowing of the skin or eyes)
• Stomach pain
Because Velpanat 400mg/100mg already contains sofosbuvir, do not take this generic HCV drug with any other medicines containing sofosbuvir 400 mg. In addition, the following medicines may also interact with this fixed-dose combination of Velpatasvir and Sofosbuvir:
amiodarone, a drug used to treat irregular heartbeats.
atorvastatin, rosuvastatin - drugs used to treat high cholesterol and to help prevent heart attacks and strokes.
rifabutin, rifampin, and rifapentine - drugs used to treat tuberculosis.
tipranavir or tipranavir/ritonavir, efavirenz, and tenofovir disoproxil fumarate (TDF) - drugs used to treat HIV.
oxcarbazepine, and phenytoin - drugs used to control seizures.
digoxin - a drug used to treat congestive heart failure and a certain irregular heartbeat (atrial fibrillation).
phenobarbital - a drug used to treat anxiety and to control seizures.
St. John’s wort - an herbal product used for anxiety or depression.
Tell your doctor or pharmacist about all the medicines you take, including any prescription/OTC drugs, vitamins, minerals, and natural supplements.
• Store Velpanat (Natco Sofosbuvir Velpatasvir) below 30°C (86°F).
• Do not store it in the bathroom. Since the heat and moisture from your shower, bath, and sink can alter the chemistry of medication, making it less effective, and in some cases dangerous to use.
• It’s also advisable to avoid the kitchen, since the heat from the stove, sink, and any hot appliances can also damage your medicine.
• Make sure to keep the pill bottles secure and out of the reach of children.
• Store medicine in a cool, dry place away from sunlight or moisture.
• Think about the safety of your pet. Remember to keep medications away from pets.
The cost is around $210 for a supply of 28 tablets.
Drugssquare is an authorized retailer, exporter, and supplier of Velpanat tablets (Velpatasvir and Sofosbuvir) in the USA (United States of America), UK (United Kingdom), Philippines, Bangladesh, United Arab Emirates (UAE), Hong Kong, Malaysia, South Africa, Australia, Serbia, Austria, Russia, Nigeria, Vietnam, Sri Lanka, Saudi Arabia, Thailand, South Korea, Peru, Chile, Indonesia, and other countries. We put patients first. If you want to purchase Natco Velpanat, place an order online with us today and we will deliver it directly to your door. Our specialty pharmacy strives to improve the lives of patients with hepatitis c virus infection by providing generic HCV drugs with huge discounts and special offers.
In order to legally purchase this medicine from DrugsSquare, you’ll require a prescription from your Registered Medical Practitioner.
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